In order to better adapt to the requirements of green exploration, promote the green development of geological drilling, and promote the progress of green exploration, optimization experiment of environment-friendly drilling fluid additives and systems was carried out with the development of the environment-friendly drilling fluid system suitable for Qinghai coal measures complex strata through indoor experimental research focused on whether the environment-friendly drilling fluid system to be developed can meet the requirements of environmental protection and drilling engineering; and production test was successfully carried out in HF-4 borehole of the Muli Coalfield comprehensive engineering geological exploration project. Indoor experimental study and field application showed that the developed environment-friendly drilling fluid reaches the national environmental protection discharge standard for biotoxicity with EC50 ≥ 30000 mg/L, has solved the technical problems of hole wall instability in complex Qinghai Coal Measures, formed an environment-friendly drilling fluid system suitable for Qinghai coal measures complex formation, and achieved good economic and social benefits, indicating that the technical achievement has a good application prospect.