At present， large-diameter borehole rescue technology is mostly used for rapid emergency rescue after the mine accident， which belongs to “post-event” passive waiting for rescue. In order to realize the transformation from traditional passive waiting for rescue to active and independent escape， the large-diameter rescue borehole is combined with the mine refuge chamber to build the disaster emergency escape system in advance. In relation to a field case of large-diameter man-wide rescue borehole drilling for the emergency escape system of the refuge chamber in a coalmine， the layout and structural design principles of rescue drilling are analyzed with focus on the selection of the drilling method， the sectional reaming process， drilling parameters， drilling fluid technology， well completion equipment and other drilling technologies， as well as the applicable conditions of large-diameter rescue drilling. The research results can provide reference for the implementation of large diameter man-wide rescue borehole drilling in similar mines.